The vision of the Strategic Research Agenda (SRA) is to provide an orientation document for European policymakers, funders, as well as the scientific and clinical communities interested in research, innovation and training related to medical applications of ionising radiation. The SRA aims to highlight current challenges and areas where research efforts are needed to ensure accessible, highest-quality, and safe personalised care for Europe’s patients, leveraging the potential of digitisation, and to advance Europe’s competitiveness in the field, based on consensus among identified stakeholders.